The Protective Effect Of Rambutan Honey On Macroscopic And Microscopic Examination Of Pancreas Rattus norvegicus Induced By Traditional Alcoholic Beverages Ciu
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Abstract
The traditional ciu alcoholic beverages is a drink made from distilled sap and sticky tape. Ciu is a type of drink that has an alcohol content of 25%. Alcoholic beverages will be toxic if consumed in excess. The pancreas is one of the organs that undergoes a process of damage when toxicmaterials or metabolites accumulate in the organ. Rambutan honey is a natural ingredient that contains flavonoid compounds. Flavonoids act as antioxidants which can reduce damage to pancreatic cells due to toxic substances. The aim of this study was to determine the protective effect of rambutan honey on the macroscopic and microscopic examination of white rats (Rattus norvegicus) induced by traditional ciu alcohol. This research is experimental with 5 treatment groups including 1 control normal, 1 control negative and 4 ciu and honey treatments. Pancreatic tissue was observed macroscopically for color and texture. Microscopic observations were observed in the form of degeneration and necrosis. The microscopic results showed that there was a color difference between the control group and the alcohol-induced honey treatment group. The results of microscopic observations were known to show degeneration and necrosis in the positive group and the treatment group. The results of the study based on the ANOVA test obtained <0.05. Based on the Anova test and Duncan test it can be concluded that rambutan honey has a protective effect on the pancreatic histopathology of white rats (Rattus norvegicus) in the form of normal cells and degenerated cells in groups K2 and K3
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References
Adityarini., S, Agung., & S, Darmanti. 2020. Kualitas Madu Lokal Berdasarkan Kadar Air, Gula Total Dan Keasaman Dari Kabupaten Magelang. Jurnal Buletin Anatomi Dan Fisiologi. (5) 1 : 18-22.
Arsyad. 2018. Pengaruh Madu Rambutan Terhadap Kadar Glukosa Darah dan Profil Lipid Pada Tikus Diabetes. Artikel Skripsi. Fakultas Kedokteran Universitas Jenderal Achmad Yani Cimahi. http://repository.unjani.ac.id/index.php?p=show_details&id=614&keywords=
Damairia, ER, Fitria, DJ 2022. Effects of Infusing Black Tea (Camellia sinensis L) and Chocolate (Theobroma cacao L) on Histopathological Features of the Hepar Rattus norvegicus. Journal of Health Analyst. Vol 11 Number 1.
Edo, JU, Artawan, IM, & Sasputra, IN. 2019. Effects of Giving Sopi Compared to Other Types of Alcohol on Histopathological Features of the Pancreas of the White Rat (Rattus norvegicus) Sprague Dawley Strain. Sandalwood Medical Journal (CMJ), 18(3), 501–505.
Fan, Z., J. Yun, S. Yu, Q. Yang & L. Song. 2019. Alcohol Consumption Can be a "Double-Edged Sword" fo Chronic Kidney Disease Patiens. Medical Science Monitor 25: 7059-7072.
Fadhmi, Mudatsir, & Syaukani, E. (2017). Perbandingan Daya Hambat Madu Seulawah Dengan Madu Trumon Terhadap Staphylococcus aureus Secara In Vitro. BIOTIK: Jurnal Ilmiah Biologi Teknologi Dan Kependidikan, 3(1), 9. https://doi.org/10.22373/biotik.v3i1.986
Faustinawati, B. 2016. The Effect of Ranitidine Administration on Histopathological Features of the Gastric Wistar Rats in Administration of Multilevel Doses of Methanol. Diponegoro Medical Journal. Vol 6, No 2, Pgs 541–548.
Ferry. 2016. Efforts to Control Traditional Drinks in the Villages of the West Malinau District. E-Journal of Integrative Governance. Vol 4, No 1, Pages 207-216.
Kaushal, G. P., K. Chandrashekar & L. A. Juncos. 2019.. Molecular Interaction Between Reactive Oxygen Spesies and Autophagy in Kidney Disease. International Journal of Molecular Science 20: 2-23.
Komang, M. S. W. N., Putu, T. N. L., & Nengah, A. I. 2014. Studi Pengaruh Lamanya Pemaparan Medan Magnet Terhadap Jumlah Sel Darah Putih (Leukosit) Pada Tikus Putih (Rattus Norvegicus). Buletin Fisika. Vol 15, No 1, Hal 31–38.
Koyu, A., Osman, G., Nurhan, G., Faruk, O., Nermin, K., Nigar, Y., Mustafa, S. 2015. Impact of Caffeic Acid Phenethyl Ester Treatment on Vancomycin-Induced Pancreatic Damage in Rats. Journal of Toxicology and Industrial Health. Pages 1-7.
Lestari, T. R. P. 2016. Menyoal Pengaturan Konsumsi Minuman Beralkohol Di Indonesia. Jurnal Aspirasi, No 86, Hal 127–141.
Nuralifah, N., Fitrawan, LO, Parawansah, P., & Trisetya, M. 2022. Histopathology of the Pancreatic Organs of Type 2 DM Rats given the Ethanol Extract of Red Gedi Leaves (Abelmoscus manihot L. Medik). Journal of Syifa Sciences and Clinical Research. Vol 4, No 1, Pgs 141–151.
Nurmalasari, Y., Rafie, R., Prasetia, T., & Adhyaksa, D. 2021. Effect of Black Seed Extract as a Preventive Effort Against Alloxan-Induced Pancreatic Histopathological Damage in Male Wistar White Rats. Prepotive: Journal of Public Health. Vol 5, No 2, Pgs 505–512.
Pribadi, ET 2017. Alcohol Abuse in Indonesia: Determinant Analysis, SWOT and CARAT. Journal of Health Science and Prevention. Vol 1, No 1, Pgs 22–37.
Rochayani, ED, Sayekti, Fitria DJ. 2022. The Effect of Infusing Black Tea (Camellia sinensis L) and Chocolate (Theobroma cacao L) on Histopathological Features of the Hepar Rattus norvegicus. Journal of Health Analyst. Vol 11 Number 1.
Villanueva-H, M., Hijona, E., Bañales, J. M., Cosme, A., & Bujanda, L. 2013. Alcohol consumption on pancreatic diseases. World Journal of Gastroenterology, Vol 1, No 5, Page 636-647.
Xiao, F. 2016. Severe acute pancreatitis. Chinese Journal of Emergency Medicine, 25(10), 1348–1350.
Yusuf, A. R., Tana, S., Saraswati, T. R., Biologi, P. S., Sains, F., & Diponegoro, U. 2021. Pengaruh Pemberian Minuman Beralkohol (Ciu) Terhadap Histomorfometri Ren Mencit (Mus musculus). Vol 6, No 2.
Zubaidah, EI, Nuril. 2015. Effects of Apple Vinegar and Salak Vinegar on Decreased Blood Glucose and Histopathology of the Pancreas of Diabetic Wistar Rats. Brawijaya Medical Journal. Vol 28 No 4.