Kajian Etnosains Pada Potensi Penggunaan Saliva untuk Penyembuhan Luka Ringan di Lampung

Silvia Nur Azizah*  -  Universitas Islam Negeri Walisongo Semarang, Indonesia
Mustajib Mustajib  -  Universitas Islam Negeri Walisongo Semarang, Indonesia
Ahsanul Buduri Agustiar  -  Universitas Islam Negeri Walisongo Semarang, Indonesia
Hafidha Asni Akmalia  -  Universitas Islam Negeri Walisongo Semarang, Indonesia

(*) Corresponding Author

Traditional medicine is the local wisdom of the Indonesian people. The people of the Jaya Sakti area of Central Lampung use saliva as a medicine to heal minor wounds. This study aims to determine the potential use of saliva in healing minor wounds. This study uses the method of observing the community. The results showed that based on the percentage of data from field observations related to the use of saliva for minor injuries in communities around Jayasakti village, Anak Tuha District, Central Lampung Regency, it is known that most people have used saliva to treat minor wounds, while other communities have never used it. or seeing other people use saliva as a remedy for minor wounds. Based on the literature review, the content contained in saliva, especially histatin, plays a major role in improving wound healing by increasing the revitalization phase, especially through increasing keratinocyte migration and proliferation. Besides, people use saliva as a medicine to heal minor wounds because they follow the habits of people who have been passed down from generation to generation and already know the content of saliva that can heal minor wounds, namely histatin and alkaline acids. In conclusion, saliva is effective to use as a wound-healing drug because of the compounds contained in saliva and people's experiences when using it.

Keywords : growth factors; wound; saliva

  1. Abbasian, B., Azizi, S., & Esmaeili, A. (2010). Effects of Rat ’ s Licking Behavior on Cutaneous Wound Healing. 13(1), 242–247.
  2. Abiko, Y., & Selimovic, D. (n.d.). The Mechanism Of Protracted Wound Healing On Oral Mucosa In Diabetes . Review. 10(3), 186–191.
  3. Andika, M., Prasko, S., & Hermien, S. (2014). Pengaruh Berkumur Air Rebusan Cabe Jawa Terhadap Ph Saliva. Kesehatan Gigi, 2(2), 239–244.
  4. Ayuningtyas, G., Harijanti, K., & Soemarijah, S. (2009). Sekresi saliva menurun dan terjadinya kandidiasis oral pada orang tua ( Penurunan sekresi saliva dan munculnya kandidosis oral pada orang tua ). 1, 6–10.
  5. Brand, H. S., Ligtenberg, A. J. M., & Veerman, E. C. I. (2014). Saliva and wound healing. Monographs in Oral Science, 24, 52–60. https://doi.org/10.1159/000358784
  6. Darmastuti, R. dan D. K. S. (2011). Kekuatan Kearifan Lokal Dalam Komunikasi Kesehatan. Jurnal Komunikasi. Jurnal Komunikasi, 3(2), 233–244.
  7. Destri, C., Nugraha, J., Anatomi, D. P., Kedokteran, F., Surabaya, U. A., Klinik, D. P., Kedokteran, F., & Surabaya, U. A. (2017). Potensi Jatropha multifida Terhadap Jumlah Fibroblast Pada Aphthous Ulcer. 19(1).
  8. Fajarwati, R., Utami, L., Ip, V. T., Wirohadidjojo, Y. W., Ilmu, B., Kulit, K., Universitas, F. K., Mada, G., & Sardjito, R. (2015). Efek Saliva Manusia Pada Proliferasi Dan Migrasi Fibroblas Jaringan Kulit Normal. Media Dermato-Venereologica Indonesiana, 42, 2–6.
  9. Gibbs, S., Roffe, S., Meyer, M., & Gasser, A. (2019). Biology of soft tissue repair: Gingival epithelium in wound healing and attachment to the tooth and abutment surface. European Cells and Materials, 38, 63–78. https://doi.org/10.22203/eCM.v038a06
  10. Hemadi, A. S., Huang, R., Zhou, Y., & Zou, J. (2017). Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment. Nature Publishing Group, 9(11), 1–8. https://doi.org/10.1038/ijos.2017.35
  11. Kavanagh, K., & Dowd, S. (2004). Histatins: antimicrobial peptides with therapeutic potential. Journal of Pharmacy and Pharmacology, 56(3), 285–289. https://doi.org/10.1211/0022357022971
  12. Kumar, B., Kashyap, N., Avinash, A., & et al. (2017). The composition , function and role of saliva in maintaining oral health : A review. Int J Contemp Dent Med Rev, 1–6. https://doi.org/10.15713/ins.ijcdmr.121
  13. Kusuma, N. (2015). Fisiologi dan Patologi Saliva. Andalas University Press.
  14. Lesmana, H., Alfianur, A., Utami, P. A., Retnowati, Y., & Darni, D. (2018). Pengobatan tradisional pada masyarakat tidung kota Tarakan: study kualitatif kearifan lokal bidang kesehatan. Medisains, 16(1), 31. https://doi.org/10.30595/medisains.v16i1.2161
  15. Lewapadang, Wanda, Tendean, Lydia E. N., P. S. A. (2015). Pengaruh Mengonsumsi Nanas (Ananas Comosus) Terhadap Laju Aliran Saliva Pada Lansia Penderita Xerostomia. E-GiGi (EG), 3(2), 454–458.
  16. Mintjelungan, C. N., & Pangemanan, D. H. C. (n.d.). Xerostomia pada Usia Lanjut di Kelurahan Malalayang Satu Timur. 1–4.
  17. Moleong, L. J. (2012). Metodologi Penelitian Kualitatif. PT Remaja Rosdakarya.
  18. Nanobiotechnol, J., Mi, B., Chen, L., Xiong, Y., Yan, C., Xue, H., Panayi, A. C., & Liu, J. (2020). Saliva exosomes ‑ derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6. Journal of Nanobiotechnology,1–14. https://doi.org/10.1186/s12951-020-00624-3
  19. Oudhoff, M. J., Kroeze, K. L., Nazmi, K., Keijbus, P. A. M., Hof, W., Fernandez-Borja, M., Hordijk, P. L., Gibbs, S., Bolscher, J. G. M., & Veerman, E. C. I. (2009). Structure‐activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1000‐fold. The FASEB Journal, 23(11), 3928–3935. https://doi.org/10.1096/fj.09-137588
  20. Pandey, A. K., & Pandey, A. K. (2014). Physiology of Saliva : An Overview Physiology of Saliva : An Overview.21(1). https://doi.org/10.14693/jdi.v0i0.186
  21. Pertiwi, U. D., & Rusyda Firdausi, U. Y. (2019). Upaya Meningkatkan Literasi Sains Melalui Pembelajaran Berbasis Etnosains. Indonesian Journal of Natural Science Education (IJNSE), 2(1),120–124. https://doi.org/10.31002/nse.v2i1.476
  22. Publisher, S., Resident, S. S., Maxillofacial, O., & Divison, S. (2015). Case Report Management of Non Healing Oral Ulcer in Diabetic Patient Using Topical Application of Epidermal Growth Factor : A Case Report. 3(8), 640–643.
  23. Rahmawati, I., Said, F., & Hidayati, S. (2015). Perbedaan pH Saliva Sebelum dan Sesudah Mengonsumsi Minuman Ringan. Jurnal Skala Kesehatan, 6(1), 11.
  24. Rodrigues Neves, C., Buskermolen, J., Roffel, S., Waaijman, T., Thon, M., Veerman, E., & Gibbs, S. (2019). Human saliva stimulates skin and oral wound healing in vitro. Journal of Tissue Engineering and Regenerative Medicine, 13(6),1079–1092. https://doi.org/10.1002/term.2865
  25. Saliva, P., Gekko, T., & Angiogenesis, L. T. (2017). Effect of Tokay Gecko ( Gekko gecko LINNAEUS , 1758 ) Saliva on Angiogenesis During Wound Healing Phase of Autotomized Tail in Common Sun Skink ( Eutropis multifasciata KUHL , 1820 ). 13(2), 253–260.
  26. Sarah J. Lowry, Hillary Blecker, Janice Camp, Butch De Castro, Steven Hecker, Saman Arbabi, Neal Traven, N. S. S. (2017). Possibilities and challenges in occupational injury surveillance of day laborers. Occupational Medicine, 53(4), 130.
  27. Shah, D., Son, K., Kalmodia, S., Lee, B., Ali, M., Balasubramaniam, A., Shukla, D., & Aakalu, V. K. (2020). Wound Healing Properties of Histatin-5 and Identification of a Functional Domain Required for Histatin-5-Induced Cell Migration. Molecular Therapy: Methods & Clinical Development, 17(June), 709–716. https://doi.org/10.1016/j.omtm.2020.03.027
  28. Sultan, A. S. (2019). crossm Evaluation of the Antifungal and Wound-Healing Properties of a Novel Peptide-Based Bioadhesive Hydrogel Formulation. 63(10), 1–11.
  29. Susanti, S. (2016). Pemetaan Penyakit Pneumonia di Provinsi Jawa Timur. Biometrika Dan Kependudukan, 5(2), 117–124.
  30. Syahrul, D., Dewi, T. P., & Sulistyawati, I., & O., G. A. P. (2017). Peranan Madu 15 % Terhadap Peningkatan pH Saliva Wanita Menopause. Interdental, 9–14.
  31. Torres, P., Castro, M., Reyes, M., & Torres, V. A. (2018). Histatins, wound healing, and cell migration. Oral Diseases, 24(7),1150–1160.https://doi.org/10.1111/odi.12816
  32. Tubert-Brohman, Ivan & Sherman, Woody & Repasky, Matthew & Beuming, T. (2013). ). Improved Docking of Polypeptides with Glide. Journal of Chemical Information and Modeling, 53(9), 1689–1699.
  33. Verrier L. (1970). Dog Licks Man. Lancet, 1, 5.Vila, T., Rizk, A. M., Sultan, A. S., & Jabra-Rizk, M. A. (2019).
  34. The power of saliva: Antimicrobial and beyond. PLoS Pathogens, 15(11), 10–16. https://doi.org/10.1371/journal.ppat.1008058
  35. Wahyudi, I. A., Magista, M., & Angel, M. (2013). Efektivitas Penggunaan Saliva Dibandingkan Povidin-Iodin 10 % Terhadap PenyembuhanLuka Pada Kutaneus Tikus Sprague Dawley The Effectiveness Of Saliva Compare To10 % Povidin- Iodine Of Healing Injury In Rats Cutaneous Sprague Dawley. Jurnal Universitas Muhammadiyah Yogyakarta, 2(1), 1–12.
  36. Wojcicki, J. M. (2003). Traditional behavioural
  37. practices, the exchange of saliva and HHV-8 transmission in sub-Saharan African populations. British Journal of Cancer, 89(10),2016–2017. https://doi.org/10.1038/sj.bjc.6601390

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