Metabolit Sekunder dari Kulit Batang Kalesi (Sphatolobus Ferrogenus) Serta Uji Inhibitor Enzim A-Glukosinade

Moch Abdussalam  -  Universitas Yarsi, Indonesia
Indah Permata Yuda  -  Universitas Yarsi, Indonesia
Juniarti Juniarti*  -  Universitas Yarsi, Indonesia

(*) Corresponding Author
DOI: 10.21580/wjc.v4i1.7991

Tanaman herbal merupakan warisan kearifan lokal dalam upaya pengobatan dan mempertahankan kesehatan masyarakat. Secara tradisional masyarakat Kalimantan tengah menggunakan tanaman aka kalesi (Sphatolobus ferrogenus) sebagai obat-obatan tradisional yang cukup luas. Penelitian ini bertujuan untuk mengisolasi senyawa metabolit sekunder yang terdapat dalam ekstrak metanol kulit batang aka kalesi (Sphatolobus ferrogenus). Isolasi dilakukan dengan tahapan ekstraksi, fraksinansi dan purifikasi. Hasil penelitian didapatkan dua isolat yang telah diuji kemurniannya dengan metode kromatografi lapis tipis. Isolat diidentifikasi dengan spektroskopi 1H-NMR dan 13C-NMR didapatkan senyawa gliseril monostearate dan sigmasterol. Kedua senyawa diuji sifat antidiabetes dengan metode inhibitor enzim α-glukosidase. Aktivitas senyawa gliseril monostearate tidak aktif, sementara sigmasterol menunjukan aktivitas yang lemah dengan IC50= 388 ppm.

Keywords: gliseril monostearate; sigmasterol; Sphatolobus ferrogenus

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