Chemical analysis of Cyproheptadine Hydrochloride in appetite-stimulating herbs marketed in Banyumas regency: ensuring consumer safety

Atika Indarwati  -  Universitas Harapan Bangsa, Indonesia
Adita Silvia Fitriana*  -  Universitas Harapan Bangsa, Indonesia
Nur Rahmawati  -  Universitas Harapan Bangsa, Indonesia

(*) Corresponding Author
DOI: 10.21580/jnsmr.v10i1.20748
Jamu, a traditional Indonesian herbal medicine, is widely used in traditional healing practices nationwide, including the Banyumas Regency. The Indonesian government has implemented restrictions that forbid the inclusion of medicinal compounds in jamu, as their unregulated usage poses possible health hazards. Cyproheptadine hydrochloride is a frequently encountered medicinal component in appetite-stimulating herbs. However, the extent of adulteration of cyproheptadine hydrochloride in appetite-stimulating herbs marketed in Banyumas Regency is undisclosed. This study purposed to analyze and quantify the presence of cyproheptadine hydrochloride in appetite-stimulating herbs that are available for sale in the Banyumas Regency. The aim was to inform customers about these herbs' possible pharmaceutical ingredient content. The study utilized a qualitative analysis of thin-layer chromatography (TLC) and a quantitative analysis with a UV-Vis spectrophotometer. Fourteen samples of appetite-stimulating herbs in powdered, capsule, and tablet forms were gathered from different areas within the Banyumas Regency. Qualitative analysis revealed cyproheptadine hydrochloride in two herbal samples, SNM TG and SNM AM. The quantitative examination revealed that the content of cyproheptadine hydrochloride in SNM TG was 10.92 mg/5g, whereas in SNM AM, it was 7.93 mg/5g. These findings indicate that there have been breaches of regulations, and individuals who ingest these herbs may be susceptible to health problems. Further investigation is required to analyze a broader range of appetite-stimulating herbal samples, particularly those in liquid form, to ascertain the level of contamination with cyproheptadine hydrochloride and provide essential data for health regulations.

Keywords: Cyproheptadine Hydrochloride; Herbs; TLC; UV-Vis Spectrophotometry.

  1. Bertrand, V., Massy, N., Vegas, N., Gras, V., Chalouhi, C., Tavolacci, M. P., & Abadie, V. (2021). Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review. Frontiers in Pediatrics, 9(September). https://doi.org/10.3389/fped.2021.712413
  2. BPOM RI. (2021). Public Warning NO.HM.01.1.2.10.21.45; Obat Tradisional Mengandung Bahan Kimia Obat.
  3. BPOM RI. (2022). Penjelasan Publik No.PW.02.04.1.4.10.22.166; Tentang Obat Tradisional Mengandung Bahan Kimia Obat.
  4. Departemen Kesehatan RI. (2014). Farmakope Indonesia Edisi V. Departemen Kesehatan Republik Indonesia.
  5. Gandjar, I. G., & Rohman, A. (2007). Kimia Farmasi Analisis. Pustaka Pelajar.
  6. Graham, M. R., Davies, B., Grace, F. M., Kicman, A., & Baker, J. S. (2008). Anabolic steroid use: Patterns of use and detection of doping. Sports Medicine, 38(6), 505–525. https://doi.org/10.2165/00007256-200838060-00005
  7. Harmita, H. (2004). Petunjuk Pelaksanaan Validasi Metode Dan Cara Perhitungannya. Majalah Ilmu Kefarmasian, 1(3), 117–135. https://doi.org/10.7454/psr.v1i3.3375
  8. Kurniarum, A., & Novitasari, R. A. (2016). Penggunaan Tanaman Obat Tradisional Untuk Meningkatkan Nafsu Makan Pada Balita. Jurnal Kebidanan Dan Kesehatan Tradisional, 1(1). https://doi.org/10.37341/jkkt.v1i1.75
  9. Lani, D. N., Dewi, Belinda, A. D., Anugerah, B., & Rosita, F. (2020). Identifikasi Bahan Kimia Obat Siproheptadin Hidroklorida dalam Jamu Penambah Nafsu Makan di Pasar Kecamatan Rengel dengan Metode Kromatografi Lapis Tipis. Jurnal Ilmiah Kesehatan, 1(1), 18–23.
  10. Lee, C., Wu, H., Kuan, M., Hung, C., Chi, C., & Fan, H. (2021). Central Anticholinergic Syndrome Due to Cyproheptadine Overdose in a Child : A Case Report and Literature Review. Tungs’ Medical Journal, 15, 40–44. https://doi.org/10.3966/207135922021061501008
  11. Longui, C. A. (2007). Glucocorticoid therapy: minimizing side effects. J Pediatr (Rio J), Nov(83), 163–177.
  12. Lovianasari, E., Fitriana, A. S., & Prabandari, R. (2021). Identifikasi Kandungan Bahan Kimia Obat Deksametason dalam Obat Tradisional Penggemuk Badan yang Dijual di Banyumas. Seminar Nasional Penelitian Dan Pengabdian Kepada Masyarakat (SNPPKM), 133–139.
  13. Madhu, M., Chanti, N. M., Gireesh, K. E., Chand, B. S., & Gopinath, C. (2016). Development and Validation of Spectroscopic Method for The Estimation of Cyproheptadine HCl in Tablet Dosage Form. Journal of Global Trends in Pharmaceutical Sciences, 7(1), 2982–2986.
  14. Mardiana, E. (2009). Identifikasi Siproheptadin Hidroklorida Dan Deksametason Dalam Sediaan Jamu Gemuk Yang Dijual Di Kios Jamu Seduhan Secara Spektrofotometri UV-VIS. Universitas Muhammadiyah Prof. Dr. Hamka.
  15. Marzuki, R. D., & Nova, A. (2018). Pembinaan Masyarakat Tentang Pemanfaatan Tanaman Binahong (Anredera cordifolia) Sebagai Obat Tradisional Di Gampong Sidorejo Langsa Lama. Jurnal Jeumpa, 5(2), 112–118. https://doi.org/10.1098/rspb.2014.1396%0Ahttps://www.uam.es/gruposinv/meva/publicaciones jesus/capitulos_espanyol_jesus/2005_motivacion para el aprendizaje Perspectiva alumnos.pdf%0Ahttps://www.researchgate.net/profile/Juan_Aparicio7/publication/253571379
  16. Nurfadillah, S. (2019). Identifikasi Bahan Kimia Obat Siproheptadin Hidroklorida Dalam Jamu Penggemuk Badan Yang Beredar di Pasar Bintara dengan Metode Kromatografi Lapis Tipis dan Reaksi Warna Periode Mei-Agustus 2019. Akademi Farmasi IKIFA Jakarta.
  17. Permenkes RI. (2012). Peraturan Menteri Kesehatan Republik Indonesia No.007 Tahun 2012 Tentang Registrasi Obat Tradisional. Menkes RI.
  18. Product Information: Periactin, C. hydrochloride. (1999). Product Information: Periactin, Cyproheptadine hydrochloride (Vol. 01).
  19. Putri, R. E., Zamroni, M., & Huda, M. K. (2021). Tinjauan Hukum Obat Tradisional Berbaha Kimia Obat. Jurnal Hukum Magnum Opus, 4(1), 1–11.
  20. Ramadhani, M. (2017). Identifikasi Bahan Kimia Obat Siproheptadin Hidroklorida dalam Jamu Penggemuk Badan dengan Metode Kromatografi Lapis Tipis. Akademi Farmasi Samarinda.
  21. Sayanna, Veeraiah, T., & Reddy, C. V. R. (2015). Determination of cyproheptadine hydrochloride in pure and pharmaceutical forms: A spectrophotometric study. Oriental Journal of Chemistry, 31(3), 1779–1786. https://doi.org/10.13005/ojc/310360
  22. Sefriadi, M. (2018). Penambahan Berbagai Konsentrasi Tepung Agar-agar Terhadap Sifat Sensori dan Kimia Permen Agar-agar Jamu Cekok. Universitas Lampung.
  23. Soebagio, Ibnu, M. S., Widarti, H. R., Munzil, & Bidiasih, E. (2005). Kimia Analitik 2. Universitas Negeri Malang.
  24. Wahyuni, A. M., Afthoni, M. H., & Rollando, R. (2022). Pengembangan dan Validasi Metode Analisis Spektrofotometri UV Vis Derivatif untuk Deteksi Kombinasi Hidrokortison Asetat dan Nipagin pada Sediaan Krim. Sainsbertek Jurnal Ilmiah Sains & Teknologi, 3(1), 239–247. https://doi.org/10.33479/sb.v3i1.181
  25. Widiyana, A. P. (2021). Validasi dari Spektrofotometri UV-Vis dan Kandungan Total Flavonoid Ekstrak Etanol dari Akar Alang-Alang (Imperata cylindrica) dan Daun Pegagan (Centella asiatica) Validatian of UV-Vis Spectrophotometry and Total Flavonoid Content Ethanolic Extract from I. Journal of Pharmaceutical Care Anwar Medika, 3(2), 126–136.

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