Red Ginger oleoresin nanoemulsion characteristics by ultrasonication

Nurma Pratiwi*    -  Politeknik Negeri Lampung, Indonesia
Chandra Utami Wirawati  -  Politeknik Negeri Lampung, Indonesia
Dwi Eva Nirmagustina  -  Politeknik Negeri Lampung, Indonesia

(*) Corresponding Author

Red ginger is a biopharmaceutical plant that is used as herbal medicine. The use of red ginger in the food industry is mainly in an emulsion form, but that is unstable and hydrophobic. The ultrasonication technique could change the emulsion into a nanoemulsion to minimize these disadvantages. This research aimed to determine the effect of ultrasonication on red ginger oleoresin nanoemulsion characteristics. The study used a completely randomized design of 4 treatments based on sonication time (0, 30, 60, and 90 minutes). The study was analyzed by ANOVA Tukey's test at P ≤ 0.05, it showed that ultrasonication affected the characteristics of red ginger oleoresin nanoemulsion. The best result shows that in 90 minutes mixed time with transparent yellow colour. It is soluble in acetone, methanol, ethanol, and aquadest solvents. The best particle size is 572.43±8.72 nm, and antioxidant activity is (IC50) 16.34 ±1.33 ppm.

©2022 JNSMR UIN Walisongo. All rights reserved.

Keywords: nanoemulsion; oleoresin; red ginger; sonication time; ultrasonication.

  1. Kemenkes, “Surat Edaran tentang Pemanfaatan Obat Tradisional, Untuk Pemeliharaan Kesehatan, Pencegahan Penyakit dan Perawatan Kesehatan.,” Kementeri. Kesehat. RI, vol. 2243, no. 02, pp. 1–5, 2020.
  2. A. C. Reddy, “Immunity: A Strong Defense against Corona Virus,” Int. J. Sci. Res., vol. 9, no. 7, pp. 127–137, 2020, doi: 10.21275/SR20626184603.
  3. Jayanudin, M. Fahrurrozi, S. K. Wirawan, and Rochmadi, “Preparation of Chitosan Microcapsules Containing Red Ginger Oleoresin Using Emulsion Crosslinking Method,” J. Appl. Biomater. Funct. Mater., vol. 17, no. 1, 2019, doi: 10.1177/2280800018809917.
  4. S. F. Hosseini, L. Ramezanzade, and D. J. McClements, “Recent advances in nanoencapsulation of hydrophobic marine bioactives: Bioavailability, safety, and sensory attributes of nano-fortified functional foods,” Trends Food Sci. Technol., vol. 109, no. October 2020, pp. 322–339, 2021, doi: 10.1016/j.tifs.2021.01.045.
  5. K. Çinar, “a Review on Nanoemulsions: Preparation Methods and Stability,” Trak. Univ. J. Eng. Sci., vol. 18, no. 1, pp. 73–83, 2017, [Online]. Available: http://dergipark.gov.tr/tujes.
  6. H. Jonassen, “Polysaccharide based nanoparticles for drug delivery applications,” University of Oslo, 2014.
  7. S. N. Kale and S. L. Deore, “Emulsion micro emulsion and nano emulsion: A review,” Syst. Rev. Pharm., vol. 8, no. 1, pp. 39–47, 2017, doi: 10.5530/srp.2017.1.8.
  8. S. Yuliasari, Hamdan, and Syafrial, “Aplikasi Nanoteknologi Untuk Pangan Fungsional Mendukung Diversifikasi Pangan,” Food Serv., vol. 71, no. 9, pp. 1475–1482, 2014.
  9. S. Kentish, T. J. Wooster, M. Ashokkumar, S. Balachandran, R. Mawson, and L. Simons, “The use of ultrasonics for nanoemulsion preparation,” Innov. Food Sci. Emerg. Technol., vol. 9, no. 2, pp. 170–175, 2018, doi: 10.1016/j.ifset.2007.07.005.
  10. L. Harmi, Pembuatan nanogingerol dari ekstrak jahe ( zingiber officinale rosc ) menggunakan homogenizer dengan kombinasi inversi komposisi dan suhu, Institut Pertanian Bogor, 2014.
  11. E. Noor, F. A. K. Haque, M. Fachrizal, and W. Niloperbowo, “The characteristic improvement of nano biomass,” IOP Conf. Ser. Earth Environ. Sci., vol. 196, no. 1, pp. 1–7, 2018, doi: 10.1088/1755-1315/196/1/012020.
  12. M. D. Cahyani, “Optimasi Tween 80 dan Etanol dalam Nanoemulsi Minyak Atsiri Jahe Emprit (Zingiber officinale var. Amarum) Sebagai Antioksidan,” Skripsi - Univ. Jember-Digital Repos. Univ. jember, pp. 1–87, 2019.
  13. H. Faradisa, “Optimasi Tween 80 Dan Etanol Dalam nanoemulsi Minyak Atsiri Jahe Gajah (Zingiber officinale var. Officinale) Sebagai Antioksidan,” Universitas Jember, 2020.
  14. A. Redha, Saniah, and D. I. Achmad, “Aktivitas Antiradikal Dpph Serbuk Nanoemulsi Oleoresin Jahe Merah Dan Karakteristik Sensoris Minumannya,” Agrofood, vol. 2, no. 1, pp. 1–6, 2020.
  15. Ö. A. Gümüşay, A. A. Borazan, N. Ercal, and O. Demirkol, “Drying effects on the antioxidant properties of tomatoes and ginger,” Food Chem., vol. 173, pp. 156–162, 2015, doi: 10.1016/j.foodchem.2014.09.162.
  16. M. I. Fakhrudin, C. Anam, and M. A. . Andriani, “Karakteristik Oleoresin Jahe Berdasarkan Ukuran dan Lama Perendaman Serbuk Jahe dalam Etanol,” Biofarmasi, vol. 13, no. 1, pp. 25–33, 2015, doi: 10.13057/biofar/f130104.
  17. E. Noor, L. Harmi, A. Maddu, and M. Yusron, “Fabrication of Nanogingerol by Combining Phase Inversion Composition and,” Res. J. Pharm. Biol. Chem. Sci., vol. 6, no. 38, pp. 38–47, 2015.
  18. S. Asadinezhad, F. Khodaiyan, M. Salami, H. Hosseini, and B. Ghanbarzadeh, “Effect of different parameters on orange oil nanoemulsion particle size: combination of low energy and high energy methods,” J. Food Meas. Charact., vol. 13, no. 4, pp. 2501–2509, 2019, doi: 10.1007/s11694-019-00170-z.
  19. N. S. P. Nuryanti, E. Martono, E. S. Ratna, and Dadang, “Characteristics and Toxicity of Nanoemulsion Formulation of Piper Retrofractum and Tagetes Erecta Extract Mixtures,” J. Hama Dan Penyakit Tumbuh. Trop., vol. 18, no. 1, p. 1, 2018, doi: 10.23960/j.hptt.1181-11.
  20. N. Jusnita and W. Syurya, “Karakterisasi Nanoemulsi Ekstrak Daun Kelor (Moringa oleifera Lamk.) (Characterization,” J. Sains Farm. Klin., vol. 6, no. 1, pp. 16–24, 2019, doi: http://doi.org/ 10.25077/jsfk.6.1.16-24.2019.
  21. S. Atun, R. Arianingrum, L. Cahyaningsih, F. A. Pratiwi, R. Kusumaningrum, and M. Khairuddean, “Formulation and characterization of quercitrin nanoemulsion isolated from dendropthoe falcata and its antioxidant activity test,” Rasayan J. Chem., vol. 13, no. 3, pp. 1347–1356, 2020, doi: 10.31788/RJC.2020.1335868.
  22. A. Redha, I. Rusiardy, and R. P. Widyastuti, “Optimasi stabilitas dan kecerahan warna pada pembuatan nanoemulasi oleoresin jahe merah,” J. Pertan. dan Pangan AGROFOOD, vol. 3, no. 1, pp. 9–14, 2021.
  23. X. Zhang et al., “Rice peptide nanoparticle as a bifunctional food-grade Pickering stabilizer prepared by ultrasonication: Structural characteristics, antioxidant activity, and emulsifying properties,” Food Chem., vol. 343, no. 1, pp. 1–33, 2021, doi: 10.1016/j.foodchem.2020.128545.
  24. A. Asadi et al., “Effect of sonication characteristics on stability, thermophysical properties, and heat transfer of nanofluids: A comprehensive review,” Ultrason. Sonochem., vol. 58, no. 104701, pp. 1–38, 2019, doi: 10.1016/j.ultsonch.2019.104701.
  25. P.-H. Li and B.-H. Chiang, “Process optimization and stability of D-limonene-in-water nanoemulsions prepared by ultrasonic emulsification using response surface methodology.,” Ultrason. Sonochem., vol. 19, no. 1, pp. 192–197, 2012, doi: https://doi.org/10.1016/j.ultsonch.2011.05.017.
  26. S. Rahmadani, Siti Sa’diah, and Sri Wardatun, “Optimasi ekstraksi jahe merah (,” Teknol. Pangan, vol. 1, no. 2, pp. 1–8, 2018.
  27. I. E. Herawati and N. M. Saptarini, “Studi Fitokimia pada Jahe Merah (Zingiber officinale Roscoe Var. Sunti Val),” Maj. Farmasetika., vol. 4, no. Suppl 1, pp. 22–27, 2020, doi: 10.24198/mfarmasetika.v4i0.25850.
  28. M. Sholihah, U. Ahmad, and I. W. Budiastra, “Aplikasi Gelombang Ultrasonik untuk Meningkatkan Rendemen Ekstraksi dan Efektivitas Antioksidan Kulit Manggis,” J. Keteknikan Pertan., vol. 5, no. 2, pp. 161–168, 2017, doi: 10.19028/jtep.05.2.161-168.
  29. M. Dzakwan and W. Priyanto, “Formulasi, karakterisasi dan aktivitas antioksidan nanosuspensi morin,” J. Ilm. Farm. Farmasyifa, vol. 3, no. 2, pp. 121–131, 2021, doi: http://doi.org/10.29313/jiff.v3i2.6062.

Open Access Copyright (c) 2022 Journal of Natural Sciences and Mathematics Research
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Journal of Natural Sciences and Mathematics Research
Published by Faculty of Science and Technology
Universitas Islam Negeri Walisongo Semarang

Jl Prof. Dr. Hamka Kampus III Ngaliyan Semarang 50185
Website: https://journal.walisongo.ac.id/index.php/JNSMR
Email:[email protected]

ISSN: 2614-6487 (Print)
ISSN: 2460-4453 (Online)

View My Stats

Lisensi Creative Commons

This work is licensed under a Creative Commons Lisensi Creative Commons .

apps