Synthesis of Curcumin Derivatives (2.5-Bis((E)-4-Hydroxy-3-Methoxy Benzylidine) Cyclopenta-1-On) from Vanillin and Its Activity Test Against Α-Glucosidase Enzymes

Rahma Diyan Martha; Danar Danar; Rini Retnosari

doi:10.21580/wjc.v5i1.8905

Synthesis of Curcumin Derivatives (2.5-Bis((E)-4-Hydroxy-3-Methoxy Benzylidine) Cyclopenta-1-On) from Vanillin and Its Activity Test Against Α-Glucosidase Enzymes

* - STIKes Karya Putra Bangsa Tulungagung, East Java, Indonesia

- Universitas Negeri Malang, Indonesia

- Universiti Kebangsaan Malaysia, Malaysia

(*) Corresponding Author

DOI: 10.21580/wjc.v5i1.8905

Abstract
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Synthesis of curcumin analogs (2.5-Bis((E)-4-Hydroxy-3-Methoxy Benzylidine) Cyclopenta-1-On) based on Claisen-Schmidt condensation using an acid catalyst and inhibition of glucosidase enzyme was carried out. The antidiabetic activity of curcumin analogs was carried out by the use of α-glucosidase enzyme from moldy rice (Oryza sativa). The curcumin analogs were synthesized by reacting the vanillin with cyclopentanone. The structure of all products was confirmed by FTIR, GC-MS, ¹H-¹³C-NMR spectrometers, and the activity enzyme. The results showed the curcumin analogs were yielded in 52.27%, respectively as yellowish-green solid. The inhibition test of the α-glucosidase enzyme showed that the curcumin analogs were the potential to inhibit the α-glucosidase enzyme with an inhibition percentage of about 94.26% in 5 mM.

Keywords: vanillin; cyclopentanone; curcumin; α-glucosidase enzymes

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