Anti-tumor and anti-cancer activity test from Nabeez Ajwa Dates (Phoenix dactilifera L.) water

Merdiana Dyah Safitri*  -  Universitas Islam Negeri Walisongo Semarang, Indonesia
Anita Fibonacci  -  Universitas Islam Negeri Walisongo Semarang, Indonesia
Rais Nur Latifah  -  Universitas Islam Negeri Walisongo Semarang, Indonesia

(*) Corresponding Author
DOI: 10.21580/jnsmr.2020.6.1.11154

Nabeez dates water is one of the fruits that is used as infused water. Dates contain flavonoids, phenols, alkaloids, and beta D-glucans which have anticancer and anti-tumor activity. Ajwa Dates have a higher phenol content than Sukkari Dates and Khalas Dates. Cancer is the number 5 deadliest disease in Indonesia and number 2 in the world after cardiovascular disease. The use of natural ingredients is an alternative for the treatment of this disease. One of the natural ingredients can be used is ajwa dates. The method of testing for anti-tumor and anti-cancer activity uses the Brine Shrimp Lethality Test (BSLT) method with shrimp larvae of Artemia salina leach as animals for testing. The results showed that the water of ajwa nabeez dates immersion for 24 hours, 48 hours, and 72 hours has the potential as anti-tumor and anti-cancer because it has an LC50 value of 676.39 ppm; 720.84 ppm; and 903.20 ppm. Phytochemical test results have shown positive samples containing tannins, phenolics, flavonoids, saponins, and alkaloids. The test results of FTIR spectophotometry resulted in the appearance of wave numbers indicating the presence of functional groups -OH, C-H, C = O, C-C (sp3), and C-O.

©2020 JNSMR UIN Walisongo. All rights reserved.

Keywords: Ajwa dates, anti tumor, anti cancer, toxicity test

  1. Abul, Husain Muslim bin al-Hajjaj al-Naisaburi, “Shohih Muslim”, Darul Fikr, Beirut, Lebanon, Hadis Nomor 3739.
  2. Alimuddin, Andi Hairil, “Sintesis Senyawa Antrakuinon Dari Eugenol Dan Ftalat Anhidrida”, 6(2): 2–7,2017.
  3. Ammar NM, Lamia T, Abou E, Nabil HS, Lalita MC and Tom JM, “Flavonoid constituents and antimicrobial activity of date (Phoenix dactylifera L.) seeds growing in Egypt”, In: Proceedings of 4th conference on research and development of pharmaceutical industries (Current Challenges). Med Arom Pl Sci Biotech, 3, 1-5, 2009.
  4. Asdar, Nurdia, Asriani Ilyas, and Maswati Baharuddin, “Identifikasi Metabolit Sekunder dari Ekstrak Aseton Biji Alpukat (Percea Americana Mill) dan Uji Toksisitas Terhadap Artemia Salina Leach”, Al-Kimia 3(Oktober): 24–35, 2017.
  5. Atun. S, “Metode Isolasi dan Identifikasi Struktur Senyawa Organik Bahan Alam”, Jurnal Konservasi Cagar Budaya Borobudur, 8, Desember, 53–61, 2014.
  6. Carey. F, “Organic Chemistry”, Journal of Molecular Structure, Vol. 18, 1973, https://doi.org/10.1016/0022-2860(73)85106- 3.
  7. Febrianti. Andita, “Pengaruh Pemberian Berbagai Dosis Ekstrak Daging Buah Kurma Ajwa (Phoenix Dactylifera) Terhadap Kadar Glukosa Darah Mencit (Mus Musculus) Bunting”, Universitas Islam Negeri Sunan Ampel, 2018.
  8. Fibonacci. A, “Menguak Sisi Sains Keajaiban Air Nabeez Kurma : Screening Fitokimia dan Pengujian Antioksidan”, Semarang: UIN Walisongo, 2019.
  9. Fibonacci. A, “Antioxidant Activity of Nabeez Water from Ajwa Palm Date Fruits (Phoenix dactylifera L) as a Favourite Drink of the Prophet Muhammad SAW”, Journal of Physics: Conference Series, 1–8, 2020.
  10. Finney. D. J, “Probit Analysis, 3rd ed”, Cambridge University Press, Cambridge, 1971.
  11. Hanani. E, Mun. A, & Sekarini. R, “Identifikasi Senyawa Antioksidan dari Kepulauan Seribu”, II, 3, 127–133, 2005.
  12. Hudaya, A. (2010). Uji Antioksidan Dan Antibakteri Ekstrak Air Bunga Kecombrang (Etlingera elatior) Sebagai Pangan Fungsional Terhadap Staphylococcus aureus dan Escherichia coli. Skripsi.Universitas Islam Negeri Syarif Hidayatullah.
  13. Ikalinus, Robertino et al. 2015. “Skrining Fitokimia Ekstrak Etanol Kulit Batang Kelor (Moringa Oleifera).” 4(1): 71–79.
  14. Mabruroh, asasu iqonil. (2015). Uji Aktivitas Antioksidan Ekstrak Tanin dari Daun Rumput Bambu (Lophatherum gracile Brongn) dan Identifikasinya. Skripsi. Universitas Islam Negeri Maulana Malik Ibrahim Malang, 64–68.
  15. Marliana, Soerya Dewi, and Venty Suryanti. 2005. “Skrining Fitokimia Dan Analisis Kromatografi Lapis Tipis Komponen Kimia Buah Labu Siam (Sechium Edule Jacq . Swartz.) Dalam Ekstrak Etanol The Phytochemical Screenings and Thin Layer Chromatography Analysis Of.” 3(1): 26–31.
  16. Marlinda, Mira, Meiske S Sangi, and Audy D Wuntu. 2012. “Analisis Senyawa Metabolit Sekunder Dan Uji Toksisitas Ekstrak Etanol Biji Buah Alpukat (Persea Americana Mill.).” 1(1): 24–28
  17. Mclaughlin, J. L., Rogers, L. L., & Anderson, J. E. (1998). The Use of Biological Assays to Evaluate Botanicals. Drug Information Journal, 32, 513–524.https://doi.org/10.1177/009286159803200223
  18. Meyer, B. N., Ferrigni, N. A., Putnam, J. E., Jacobsen, L. B.,Nichols, D. E., & Mclaughlin, J. L. (1982). Brine Shrimp : A Convenient General Bioassay for Active Plant Constituents. Journal of Medicinal Plant Research, 45(Januari 1982), 31–34.
  19. Mutia, D. (2010). Uji Toksisitas Akut Ekstrak Etanol Buah Anggur (Vitis vinifera) Terhadap Larva Artemia salina Leach dengan Metode Brine Shrimp Lethality Test (BSLT). Universitas Diponegoro.
  20. Noor, I. (2010). Isolasi dan Karakterisasi ß -Glukan dari Tubuh Buah Jamur Tiram Putih (Pleurotus ostreatus) dengan Metode Spektroskopi UV-Visibel dan FTIR. Universitas Islam Negeri Syarif Hidayatullah.
  21. Noor, Y.R., Khazali, M., Suryadiputra, I.N.N. 1999. Panduan Pengenalan Mangrove di Indonesia. Bogor: PHKA/WI- IP
  22. Perron, R. N. dan Brumaghim, L. J. 2009. A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding. Cell Biochem Biophys, (53): 75 – 100.
  24. Pranamuda, H., Giarni, R., Pradana, A., Mahsunah, I. S. A., & Dewi, D. (2012). Aplikasi Beta Glukan Sebagai Bahan Berkhasiat Imunomodulator dan Antikanker. Prosiding InSINas, (November 2012), 70–73.
  25. Putri, A. A. ., & Hidajati, N. (2015). Uji Aktivitas Antioksidan Senyawa Fenolik Ekstrak Metanol Kulit Batang Tumbuhan Nyiri Batu (Xylocarpus moluccensis). Unesa Journal of Chemistry, 4(Januari 2015), 1–6.
  26. Putri, E. B. P., Putri, F. K., & Sulaiha, S. (2020). Perbandingan Kadar Flavonoid dan Vitamin C pada Infused Water Goji Berry (Lycium barbarum) dan Air Nabeez Kurma (Phoenix dactylifera L.). MTPH Journal, 4(Maret 2020), 32–37.
  27. Rahmani, A. H., Aly, S. M., Ali, H., Babiker, A. Y., Srikar, S., & Amjad, A. (2014). Therapeutic Effects of Date Fruits (Phoenix dactylifera ) in the Prevention of Diseases Via Modulation of Anti-Inflammatory, Anti-Oxidant, and Anti-Tumour Activity. Int Journal Clin Med, 7(Maret 2014), 483–491.
  28. Rolliana, E. R. (2010). Uji Toksisitas Akut Ekstrak Etanol Daun Kamboja (Plumeria alba L.) Terhadap Larva Artemia salina Leach dengan Metode Brine Shrimp Lethality Test (BSLT). Universitas Diponegoro.
  29. Saleh, E. A., Tawfik, M. S., & Abu-tarboush, H. M. (2011). Phenolic Contents and Antioxidant Activity of Various Date Palm (Phoenix dactylifera L .) Fruits from Saudi Arabia. Food and Nutrition Sciences, 2(December 2011), 1134–1141. https://doi.org/10.4236/fns.2011.210152
  30. Sastrohamidjojo, Hardjono. 2001. Spektroskopi. Yogyakarta: Liberty
  31. Savage, G. P. 2003. SAPONINS. Encyclopedia of Food Sciences and Nutrition, 5095–5098. doi:10.1016/b0-12-227055-x/01050-6-
  32. Ullah, M. O., Haque, M., Urmi, K. F., Zulfiker, A. H., Anita, E. S., & Hamid, K. (2013). Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh. Asian Pacific Journal of Tropical Biomedicine, 3(1), 1–7.

Open Access Copyright (c) 2020 Journal of Natural Sciences and Mathematics Research
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Journal of Natural Sciences and Mathematics Research
Published by Faculty of Science and Technology
Universitas Islam Negeri Walisongo Semarang

Jl Prof. Dr. Hamka Kampus III Ngaliyan Semarang 50185
Website: https://journal.walisongo.ac.id/index.php/JNSMR
Email:jnsmr@walisongo.ac.id

ISSN: 2614-6487 (Print)
ISSN: 2460-4453 (Online)

View My Stats

Lisensi Creative Commons

This work is licensed under a Creative Commons Lisensi Creative Commons .

apps