Pengaruh Sinbiotik Kefir Tepung Pisang Batu (Musa balbisiana) terhadap Kadar Kolesterol Total dan Kadar Trigliserida Tikus Model Sindrom Metabolik

Diana Martha Ariesta Sari*  -  Universitas Pembangunan Nasional "Veteran" Jakarta, Indonesia
Taufik Maryusman  -  Universitas Pembangunan Nasional "Veteran" Jakarta, Indonesia
Santi Herlina  -  Universitas Pembangunan Nasional "Veteran" Jakarta, Indonesia

(*) Corresponding Author
DOI: 10.21580/ns.2020.4.1.4335
This study was conducted to analyze the effects of banana (Musa balbisiana) flour kefir synbiotic on total cholesterol level and triglyceride level of Metabolic Syndrome rats model. This research used a true experimental method with pre-post test control group design. The number of 24 rats model were randomly divided into four groups, i.e. K– (healthy rats, standard diet), K+ (Metabolic Syndrome rats, standard diet), PI (Metabolic Syndrome rats, standard diet and synbiotic 1,8 ml/200grBW/day), and PII (Metabolic Syndrome rats, standard diet and synbiotic 3,6 ml/200grBW/day), with intervention duration of 3 weeks. Blood draws were carried out at the beginning and end session of the intervention to analyze total cholesterol and triglyceride levels. The data from the measurement of total cholesterol and triglyceride levels before and after the intervention were then analyzed using the Paired T-Test. The results of the Paired T-Test showed differences (p<0,05) in total cholesterol and triglyceride levels before and after intervention in all groups. The banana flour kefir synbiotic has been shown to reduce cholesterol and triglyceride levels in rats.

Penelitian ini dilakukan untuk menganalisis pengaruh sinbiotik kefir tepung pisang batu terhadap kadar kolesterol total dan kadar trigliserida tikus model sindrom metabolik. Desain penelitian ini eksperimental murni dengan pre-post test control group design. Sebanyak 24 tikus Sprague dawley jantan dibagi secara acak menjadi empat kelompok, yaitu K– (tikus sehat, pakan standar), K+ (tikus sindrom metabolik, pakan standar), PI (tikus sindrom metabolik, pakan standar dan sinbiotik 1,8 ml/200gr BB tikus/hari), dan PII (tikus sindrom metabolik, pakan standar dan sinbiotik 3,6 ml/200gr BB tikus/hari) dengan intervensi 3 minggu. Pengambilan darah dilakukan pada awal dan akhir intervensi untuk menganalisis kadar kolesterol total dan trigliserida. Kadar kolesterol total dan trigliserida sebelum dan setelah intervensi dianalisis dengan uji Paired T-Test. Hasil penelitian menunjukkan bahwa terdapat perbedaan nyata (p<0,05) kadar kolesterol total dan kadar trigliserida sebelum dan setelah intervensi pada semua kelompok. Sinbiotik kefir tepung pisang batu terbukti mampu menurunkan kadar kolesterol dan trigliserida tikus.

Keywords: Synbiotic; kefir; Musa balbisiana; cholesterol; triglyceride; Sinbiotik; kefir; pisang batu (Musa balbisiana); kolesterol; trigliserida

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