Pengaruh Kombinasi Vitamin C pada Suplementasi Zat Besi terhadap Kadar Hemoglobin: Meta-Analisis

Hamidah Nur Aini; Debby Endayani Safitri

doi:10.21580/ns.2021.5.2.6683

Pengaruh Kombinasi Vitamin C pada Suplementasi Zat Besi terhadap Kadar Hemoglobin: Meta-Analisis

* - Program Studi Ilmu Gizi Fakultas Ilmu-Ilmu Kesehatan Universitas Muhammadiyah Prof. Dr. Hamka, Indonesia

- Program Studi Ilmu Gizi Fakultas Ilmu-Ilmu Kesehatan Universitas Muhammadiyah Prof. Dr. Hamka, Indonesia

(*) Corresponding Author

DOI: 10.21580/ns.2021.5.2.6683

Abstract
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This study was conducted to determine the effect of iron supplementation with a combination of vitamin C on hemoglobin levels. This study is a meta-analysis of research published between 2010 and 2020. The identification of research articles using the Medline®, PNRI, and Google Scholar databases. The dependent variable of this study was hemoglobin levels with the independent variable iron with and without vitamin C. The analysis carried out in the study was homogeneity test, combined mean, and sensitivity test. The results of the study with the homogeneity test showed that the research data was heterogeneous, the difference in the combined average in the study was 0.79 (95% CI: -0.60-1.40). After the sensitivity test was carried out, the combined mean obtained values that were much different. Based on the meta-analysis conducted, iron supplementation combined with vitamin C was able to increase hemoglobin by 0.79 higher than iron supplementation without vitamin C. Iron supplementation for anemia prevention is more effective with vitamin C.

Penelitian ini dilakukan untuk menentukan pengaruh suplementasi zat besi dengan kombinasi vitamin C terhadap kadar hemoglobin. Penelitian ini merupakan meta-analisis terhadap penelitian yang dipublikasikan pada rentang tahun 2010 hingga 2020 dengan studi eksperimental. Identifikasi artikel penelitian menggunakan basis data Medline®, PNRI, dan Google Scholar. Variabel dependen penelitian ini adalah kadar hemoglobin dengan variabel independen zat besi dengan dan tanpa vitamin c. Analisis yang dilakukan pada penelitian adalah uji homogenitas, mean gabungan, dan uji sensitivitas. Hasil penelitian dengan uji homogenitas menunjukkan data penelitian heterogen, perbedaan rata-rata gabungan pada penelitian adalah 0,79 (95% CI: -0,60-1,40). Setelah dilakukan uji sensitivitas, mean gabungan mendapatkan nilai yang jauh berbeda. Berdasarkan hasil meta-analisis yang telah dilakukan, suplementasi zat besi dikombinasikan dengan vitamin C mampu meningkatkan hemoglobin sebanyak 0,79 lebih tinggi dibandingkan suplementasi zat besi tanpa vitamin C. Suplementasi zat besi untuk pencegahan anemia lebih efektif dilakukan dengan disertai vitamin C.

Keywords: hemoglobin levels; iron; supplementation; vitamin C; kadar hemoglobin; zat besi; suplementasi; vitamin C

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