Instagram addiction is a social phenomenon among adolescents that has been scantily researched. This study aims to empirically examine the effect of type D personality (social disinhibition and negative affectivity), self-esteem, and fear of missing out (FoMO) on Instagram addiction among teenagers. A total of 259 participants, type D personalities with severe Instagram addiction who live in Jakarta Greater Area obtained through screening results (based on their total scores). This research used snowball sampling dan regression techniques for data collection and analysis. Data analysis showed that all predictors affected 56.9% of Instagram addiction cases. Partially, it is known that only negative affectivity (one of type D personality factors) has no influence on Instagram addiction, which means that, the role of pure internal factors such as personality type D is not as significant as the combination of both external and internal factors such as fear of missing out and self-esteem in influencing Instagram addiction.